**Elena S. Dimitrova**

**PERSONAL DATA**

**US Citizen **

Associate
Professor

O-303
Martin Hall

Department
of Mathematical Sciences

Clemson
University

Clemson,
SC 29634

864/656-1524

http://edimit.people.clemson.edu/

**EDUCATION**

Ph.D.,
Virginia Tech, 2006, Mathematics

M.S.,
Virginia Tech, 2003, Mathematics

B.A.,
American University in Bulgaria, 2001, Computer Science

**PROFESSIONAL EXPERIENCE**

Coordinator
of Undergraduate Studies, Department of Mathematical Sciences, Clemson
University, August 2018-present.

Faculty
Scholar, School of Health Research, Clemson University, April 2015-March 2018.

Associate
Professor of Mathematical Sciences, Clemson University, August 2012-present.

Assistant
Professor of Mathematical Sciences, Clemson University, August 2006-July 2012.

**PUBLICATIONS**

Murrugarra,
D., Dimtrova, E.S. Intervention Strategies in Multistate Discrete Networks. In preparation.

Koshy,
S., Dimitrova, E.S. From chaos to permanence using control theory. Submitted.

S. Ha,
E. Dimitrova, D. Altarawy, H. Hosamadine, D. Deb, R. Hilmer, M. Ansariola, M.
Megraw, J. Setubal, F. Katagiri, J. Glazebrook, B. Tyler, J. McDowell, S.
Hoops, R. Laubenbacher PlantSimLab - A Modeling and Simulation Web Tool for
Plant Biologists. Submitted.

Dimitrova,
E.S., He, Q., Robbiano, L., Stigler, B. Small Gršbner fans of ideals of points.
Submitted.

Dimitrova,
E.S., Caromile, L.A., Laubenbacher, R., Shapiro, L. (2018). The innate immune
response to ischemic injury: a multiscale modeling perspective. BMC Systems
Biology, 12:50.

Dimitrova,
E.S. (2017). Discrete-Time Dynamical Systems. In ÒHandbook of Discrete and
Combinatorial Mathematics,Ó 2nd Ed, Ed. Douglas Shier. CRC Press.

Dimitrova,
E.S. and Laubenbacher, R. (2017). Boolean models in immunology. In ÒSystem
Immunology: An Introduction to Modeling Methods for Scientists,Ó Eds. Das, J.
and Jayaprakash, C. Taylor & Francis Group.

Murrugarra,
D. and Dimitrova, E.S. (2015). Molecular network control through Boolean
canalization. EURASIP Journal on Bioinformatics and Systems Biology, 2015:9.

Dimitrova,
E.S., Yordanov, O.I., Matache, M.T. (2015). A difference equation for tracking
perturbations in systems of Boolean nested canalyzing functions. Physical
Review Letters E, 91(6), 062812.

Le Pape,
S., Dimitrova, E.S., Hannaert, P., Konovalov, A.,Volmer,
R., Ron, D., Thuillier, R., Hauet, H. (2014). Polynomial algebra as a tool to
identify potential therapeutic targets: an application to ischemia-reperfusion
injury. FEBS Letters, 588(17), pp. 3062-7.

Stigler,
B. and Dimitrova, E.S. (2014). Data Identification and Characterization for
Improving Gene Network Inference. Bulletin of Mathematical Biology, 76(11), pp.
2923-40.

Dimitrova,
E.S. and Stigler, B. (2013). Inferring the Topology of Gene Regulatory
Networks: An Algebraic Approach to Reverse Engineering. In ÒMathematical
Concepts and Methods in Modern Biology,Ó Eds. Hodge, T. and Robeva, R.
Elsevier.

Layne,
L., Dimitrova, E.S., Macauley, M. (2012). Nested canalyzing depth and network
stability. Bulletin of Mathematical Biology, 74(2), pp. 422-433.

Dimitrova,
E.S., Mitra, I., Jarrah, A.S. (2011). Probabilistic polynomial dynamical
systems for reverse engineering of gene regulatory networks. EURASIP J. on
Bioinformatics and Systems Biology, 2011:1, pp. 1-33.

Dimitrova,
E.S., Garcia-Puente, L.D., Hinkelmann, F., Jarrah, A.S., Laubenbacher, R.,
Brandilyn Stigler, Stillman, M., Vera-Licona, P. (2011). Parameter estimation
for Boolean models of biological networks. Journal of Theoretical Computer
Science, 412(2011), pp. 2816-2826.

Dimitrova, E. S. (2010). Estimating the relative volumes of the cones in
a Gršbner fan. Mathematics in Computer Science, 3(4), pp. 457-466.

Dimitrova,
E.S., McGee, J., Laubenbacher, R., Vera Licona, P. (2010). Discretization of
time series data. Journal of Computational Biology, 17(6), pp. 853-868.

Laubenbacher,
R., Jarrah, A.S., Dimitrova, E.S., Stigler, B., Vera-Licona, P. (2009). System
identification for discrete polynomial models of gene regulatory networks. 15th
IFAC Symposium on System Identification (SYSID 2009), Volume 15, Part 1, pp.
11-17.

Dimitrova,
E.S., Zardecki, A. (2008).
Forecasting polynomial dynamics. Applied Mathematics and Computation,
204(1), pp. 233-239.

Dimitrova,
E.S., Jarrah, A.S., Laubenbacher, R., Stigler, B. (2007). A Gršbner fan method
for biochemical network modeling. In Proc. International Symposium on Symbolic
and Algebraic Computation (ISSAC), ACM, pp. 122-126.

Dimitrova
E.S., Yordanov, O. (2001). Statistics of some low-dimensional chaotic flows.
International Journal of Bifurcation and Chaos, 11(10), pp. 2675-2682.

**PRESENTATIONS **

__Invited presentations__

Dimitrova, E.S.,
ÒUnique Reduced Gršbner Bases of Ideals of Points,Ó Discrete Math Days in the
Northeast, University of New England, Biddeford, ME (May 5, 2018).

Dimitrova, E.S.
ÒA discrete multiscale modeling perspective to the innate immune response to
ischemic injury,Ó Joint Mathematics Meetings, San Diego, CA (January 2018).

Dimitrova, E.S.,
ÒMolecular Network Control Through Boolean Canalization,Ó AMS Fall Southeastern
Sectional Meeting, University of Central Florida, Orlando, Orlando, FL

(September, 2017).

Dimitrova, E.S.,
ÒVanishing ideals,Ó CanaDAM 2017, Ryerson University, Toronto, ON, Canada (June
2017).

Dimitrova, E.S.,
ÒUnique Reduced Gršbner Bases of Ideals of Points,Ó Colloquium
talk, Dartmouth College, Hanover, NH (October 2016).

Dimitrova, E.S.,
ÒAlgebraic models for gene regulatory networks,Ó Mathematical Biology and Ecology Seminar, Georgia Tech, Atlanta, GA
(June 2016).

Dimitrova, E.S.,
ÒProperties and applications of vanishing ideals of points over finite fields,Ó
Meeting on Algebraic Geometry for Applications, Clemson University, Clemson, SC
(April 2016).

Dimitrova, E.S.,
ÒProperties and applications of vanishing ideals of points over finite fields,Ó
Algebra and Discrete Mathematics Seminar and Graduate Student Combinatorics Conference, Clemson University,
Clemson, SC (March 2016).

Murrugarra D.
and Dimitrova, E., ÒControl methods for Boolean networks,Ó Eighth international
Symposium on Biomathematics and Ecology: Education and Research (BEER 2015), Illinois
State University, Normal, IL (October 2015).

Dimitrova,
E.S., Yordanov, O.I., Matache, M.T., A difference equation for tracking
perturbations in systems of Boolean nested canalyzing functions. KNOWeSCAPE 2015, European
Cooperation in Science and Technology, Mons, Belgium (September 2015).

Dimitrova, E.S.,
ÒAlgebraic models in systems biology,Ó Department of Mathematics, University of
Kentucky, Lexington, KY (December 2014).

Dimitrova, E.S.,
ÒCanalyzation in mathematical modeling,Ó Keynote address, KNOWeSCAPE 2014,
European Cooperation in Science and Technology, Thessaloniki, Greece (November
2014).

Dimitrova, E.S.,
ÒCanalyzation in modeling gene regulatory networks,Ó Biomathematics and
Ecology: Education and Research 2013 (BEERÕ13), Marymount University,
Arlington, VA (October 2013).

Dimitrova, E.S.
and Stigler, B., ÒDesign of experiment for biological network inference,Ó Conference
on Applied Algebraic Geometry (AG13), Colorado State University, Fort Collins,
CO (August 2013).

Dimitrova, E.S.
and Stigler, B., ÒData characterization and identification for network
inference,Ó Spring Central Sectional AMS Meeting, Iowa State University, Ames, IA
(April 2013).

Dimitrova, E.S.,
ÒModeling gene regulatory networks,Ó Southern Methodist University, Department
of Mathematics, Dallas, TX (April 2012).

Dimitrova, E.S.,
ÒPerturbation spread in Boolean networks,Ó George Washington University, AMS special
session on Dynamics of Complex Networks, Washington, DC (March 2012).

Dimitrova, E.S.,
ÒModeling gene regulatory networks with canalyzing functions,Ó Medical College
of Georgia, Augusta, GA, (March 2011).

Dimitrova, E.S.,
Layne, L., ÒDiscrete models of biological networks,Ó UC Santa Cruz, Department
of Bioengineering, Santa Cruz, CA, (August 2010).

Dimitrova, E.S.,
Layne, L., ÒSome properties of nested canalyzing and partially nested
canalyzing functions,Ó Department of Mathematics, UC Berkeley, Berkeley, CA (July
2010).

Mitra, I., Dimitrova,
E.S., Jarrah, A.S., ÒStochastic polynomial dynamical model of the yeast cell
cycle,Ó APS 2010 Meeting, Portland, OR (March 2010).

Dimitrova, E.S.,
ÒProbabilistic dynamical systems for reverse engineering of the yeast cell
cycle network,Ó AMS 2009 Central Section Meeting, Waco, TX (October 2009).

Dimitrova, E.S.,
ÒParameter estimation for a drought-related gene network in rice,Ó SAMSI
Transition Workshop: Algebraic Methods in Systems Biology and Statistics,
Research Triangle, NC (June 2009).

Dimitrova, E.S.,
ÒDiscovering gene networks in rice,Ó SIAM Chapter at Virginia Tech, Blacksburg,
VA (April 2009).

Dimitrova, E.S.,
Jarrah, A.S., ÒProbabilistic polynomial systems for the reverse engineering of
stochastic gene regulatory networks,Ó Joint
Meeting of the American Mathematical Society and Shanghai Mathematical Society,
Fudan University, Shanghai, China (December 2008).

Dimitrova, E.S.,
ÒConjecturing variable dependencies in biochemical networks,Ó Visitors Day, Virginia Tech, Blacksburg, VA (March 2007).

Dimitrova, E.S.,
ÒUsing the Gršbner fan of an ideal for polynomial model selection,Ó AMS Spring
Southeastern Section Meeting, Special Session on
Applicable Algebra, Davidson College, Davidson, NC (March 2007).

Dimitrova, E.S.,
ÒUsing the Gršbner fan of an ideal for polynomial model selection,Ó Computational Mathematics Seminar, Department of Mathematical Sciences,
Clemson University (February 2007).

Dimitrova, E.S.,
ÒInferring dependencies in biochemical networks,Ó Third SC-INBRE Bioinformatics Research Symposium, Clemson University (January
2007).

Dimitrova, E.S.,
ÒPolynomial models for systems biology: a combinatorial method for model
selection,Ó Bioinformatics Seminar, Clemson
University (November 2006).

Dimitrova, E.S.,
Layne, L., ÒTerm order effect on polynomial models for systems biology,Ó** **National EPSCoR Conference, Lexington, KY (November 2006).

Dimitrova, E.S.,
ÒUsing the Gršbner fan of an ideal for polynomial model selection,Ó ADM
Seminar, Mathematical Sciences, Clemson University (October 2006).

Dimitrova, E.S.,
ÒExperimental data preprocessing for reverse engineering,Ó Mathematical
Biology, Institute for Advanced Study / Park City Mathematics Institute, Park
City, UT (July 2005).

Dimitrova, E.S.,
ÒDiscretization of biological data,Ó 1^{st} Annual Faculty Retreat of
Virginia Bioinformatics Institute, Homestead Resort, VA (May 2005).

Dimitrova, E.S.,
ÒTime series discretization for reverse engineering of gene networks,Ó Bulgarian
Academy of Science, Sofia, Bulgaria (January 2005).

Dimitrova, E.S.,
ÒTime series discretization for reverse engineering of gene networks,Ó SIAM
Student Chapter at Virginia Tech, Blacksburg, VA (November 2004).

Dimitrova, E.S., ÒA graph-theoretic method for the discretization of
gene expression measurements,Ó SACNAS National Conference, Austin, TX, (October
2004).

Dimitrova, E.S.,
Stigler, B., Laubenbacher, R., ÒContinuous and discrete modeling of biological
systems,Ó Mathematical Methods in Bioinformatics, Pre-conference Mathematics
Institute Session, Austin, TX (October 2004).

Dimitrova, E.S.,
Yordanov, O., ÒStatistics on low-dimensional chaotic flows,Ó Summer School in
Bifurcation and Chaos, Pamplona, Spain (June 2000).

__Contributed presentations__

Dimitrova, E.S.
and Koshy, S., ÒLong-term survival and chaotic dynamics in population models,Ó Joint
Mathematics Meetings, Seattle, WA (January 2016).

Dimitrova, E.S.,
ÒData identification for gene network inference with algebraic models,Ó 2015 Annual Meeting for the Society of Mathematical Biology, Atlanta, GA
(July 2015).

Dimitrova, E.S.,
ÒA computational algebra method for biochemical network modeling,Ó Joint Mathematics Meetings, San Diego, CA (January 2008).

Dimitrova, E.S.,
ÒA Gršbner fan method for
biochemical network modeling,Ó International Symposium on Symbolic and
Algebraic Computation, University of Waterloo, Ontario, Canada, (July 2007).

Dimitrova, E.S.,
Stigler, B., ÒApplications of the Gršbner fan to gene network reconstruction,Ó East
Coast Computer Algebra Day, Shepherdstown, WV (May 2008).

Dimitrova, E.S.,
ÒMathematical modeling of biochemical networks,Ó Workshop
for Young Researchers in Mathematical Biology, MBI, The Ohio State University,
Columbus, OH (March 2007).

Dimitrova, E.S.,
ÒModeling of gene networks,Ó First Year Graduate Student Seminar, Department of Mathematical Sciences, Clemson University (March 2007).

Dimitrova, E.S., ÒTime series discretization for reverse engineering of
gene networks,Ó Workshop for Young Researchers in
Mathematical Biology, MBI, The Ohio State University, Columbus, OH (March
2006).

**OTHER PROFESSIONAL ACTIVITIES**

Panelist, National Science Foundation, Arlington, VA
(March 2018).

Organizer,
ÒAlgebraic Geometry Methods for Discrete Dynamical Systems,Ó Minisymposium at
SIAM Conference on Applied Algebraic Geometry, Georgia Tech, Atlanta, GA
(August 2017).

Organizer,
ÒBiological Networks,Ó Invited minisymposium at CanaDAM 2017, Ryerson
University, Toronto, ON, Canada (June 2017).

Panelist,
National Science Foundation, Arlington, VA (May 2017).

Co-organizer,
Special Session on Algebraic and Combinatorial Methods in Mathematical Biology,
AMS Spring Southeastern Sectional Meeting, University of Georgia, Athens, GA (March
2016).

Co-organizer,
Algebraic and Combinatorial Approaches in Systems Biology (SMB), University of
Connecticut, Farmington, CT (July 2015).

Panelist,
National Science Foundation, Arlington, VA (July 2014).

Panelist,
NSF EPSCoR (May 2012).

Panelist,
National Science Foundation, Arlington, VA (November 2011).

Panelist,
National Science Foundation, Arlington, VA (April
2011).

Panelist,
National Science Foundation, Arlington, VA (April
2010).

Organizer,
Statistical and Applied Mathematical Sciences Institute (SAMSI), Program on Algebraic Methods in Systems Biology and Statistics: Discrete Models in
Systems Biology Workshop, Research Triangle Park, NC (December 2008).

Reviewing
Editor, Frontiers in Systems Biology.

**Honors
and Awards**

2011
Mathematical Sciences Faculty Teaching Award, Department of Mathematical
Sciences, Clemson University, (2011).

Project NExT Fellowship (a program of the MAA), AMS,
(2006-07).

**FUNDED GRANT PROPOSALS
(Amounts in parentheses are DimitrovaÕs portion)**

ÒSoutheast Center of Mathematics and Biology,Ó NSF and Simons
Foundation, PI on subaward, $10,000,000, ($578,235), (2018-23).

ÒCollaborative Research: Selection methods for algebraic design of
experiments,Ó NSF, PI, $200,000, ($100,000), (2017-20).

Conference grant, ACSB 2015: A Conference on Algebraic and
Combinatorial Approaches in Systems Biology, NSF, co-PI, $15,000, ($3,000),
(May 2015). Awarded.

ÒData selection for unique model identification,Ó NSF, PI, $200,000,
($100,000), (2014-17).

AWM-NSF Travel Grant, PI, $892, (2013).

ÒDeveloping discrete network models to discover transcriptional
regulation of peach fruit color,Ó University Research Grant Committee (URGC), PI,
$9,138, (2011).

ÒAcquisition of Large-Memory, Many-Core Compute Node for Mathematical
Science Research,Ó NSF, co-PI, $127,196, ($10,175), (2010-11).

**GRADUATE STUDENT ADVISING**

Molly Hoenecker (MS), ÒUnique Gršbner bases and neural codes.Ó
(Expected April 2018).

Sherli Koshy Chenthittayil (PhD), ÒChaos to Permanence-Through Control
Theory,Ó (April 2017).

Sherli Koshy Chenthittayil (MS), ÒDetermining Parameters Leading to
Chaotic Dynamics in Systems,Ó (May 2015).

Abhishek Pandey (PhD; Co-advisor: Jan Medlock), ÒModeling and
Optimization of the Allocation of a New Dengue Vaccine,Ó (April 2014).

Praveen Nalla (MS), ÒA Probabilistic Model of Perturbation Spread in Networks
of (Partially) Nested Canalyzing Functions,Ó (December 2013).

Kaitlin Woskoff (MS), ÒCorrespondence between the Steady States of
Continuous and Discrete Models,Ó (May 2012).

Margaux Evans (MS), ÒAdaptive Dynamics via *R*_{0} Maximization,Ó (May 2012).

Ryan Harper (MS), ÒModeling Influenza Infections," (August 2012).

Lori Layne (PhD), ÒProperties and Applications of Nested and Partially
Nested Canalyzing Functions,Ó (May 2011).

Indranil Mitra (MS), ÒReverse Engineering of the Yeast Cell-Cycle NetworkÓ
(December 2009).

Sarah L. Edwards (MS), ÒPolynomials and Graph ColoringsÓ (May 2008).

Lori Layne (MS), ÒCommunity Structures in Biological NetworksÓ (December
2007).

**UNDERGRADUATE STUDENT ADVISING **

** **Curriculum
advisor,
Undergraduate Mathematical Sciences students with concentration in biology (2013-present).

**PROFESSIONAL MEMBERSHIPS**

American Mathematical Society (AMS)

Society for Industrial and Applied
Mathematics (SIAM and SIAG on Algebraic Geometry)

Society for Mathematical Biology (SMB)

**TEACHING**

__Undergraduate Courses__

Introduction to Proof, F15, Sp16, F16, F18

Calculus of One Variable I, Sum12

Introduction to Mathematical Models, F11, F12, F12

Differential Equations, Sp11, Sum11, Sp13, F13

Discrete Mathematical Structures I, F10

Elementary Statistical Inference, Sum10, Sum11

Calculus of One Variable II, Sum10, Sum12, Sum13, Sum14, Sum15, Sum16

Abstract
Algebra, Sp09, Sum09, Sp11, F11, Sp12, F12, Sp15

Linear Algebra, Sp08, F10, Sp15, Sp17, Sp18

Introduction to Business Statistics, Sp07, F07, F08, F09, Sp10

Statistical Methods I, F06

Calculus I for Engineers, F03, Sp03

Elementary
Calculus with Matrices, F02, Sp02

__Graduate Courses__

Discrete Mathematical Methods for Modeling & Simulation
of Biological Systems, Sp10

Computational Algebra, Sum08

Matrix Analysis, F07, Sp08, F08, Sp18

**UNIVERSITY AND PUBLIC
SERVICE**

Chair,
Mathematical Sciences Undergraduate Affairs Committee (F18-present).

Member,
College of Science Curriculum Committee (F18-present).

Reviewer,
Office of Research Development (ORD) (Summer 2018).

Member,
Mathematical Sciences Interim Chair Search Committee (Sp18).

Member,
Mathematical Sciences Graduate Affairs Committee (F17-present).

Freshmen
advising, Summer 2017, Summer 2018.

Teaching
Mentor to Assistant Professor Svetlana Poznanovik, F13-Sp18.

Member,
Mathematical Sciences Council (Sp15-Sp16).

Member,
Associate Dean of the Graduate School Search Committee (Sp16).

Member,
Commutative Algebra Search Committee (Sp15).

Member,
Mathematical Sciences Teaching Award Committee (2012-2014).

Co-author,
Algebra and Discrete Mathematics Qualifying Exam (2008, 2009, 2018).

Coordinator, Algebra and Discrete Math Seminar,
Dept. of Mathematical Sciences (2007-11).

Chair,
Bioinformatics Search Committee (2007-08).

**JOURNAL REFEREEING **

Reviewing Editor,
Frontiers in Systems Biology

Referee, BMC Systems
Biology

Referee, Frontiers in
Genetics

Referee, Frontiers in
Physiology

Referee, Methodology and
Computing in Applied Probability

Referee, Bioinformatics

Referee, IET Systems
Biology

Referee, Journal of
Mathematical Biology

Referee, Open
Bioinformatics Journal

Referee, Bulletin of
Mathematical Biology

Referee, Artificial
Intelligence in Medicine

Referee, *In Silico*
Biology

Referee,
Theoretical Computer Science

Referee,
Open
Bioinformatics Journal

Referee,
Entropy

Referee,
Computational Biology and Bioinformatics

Referee, Computational and Mathematical Methods in
Medicine

Referee, Spora: A Journal of Biomathematics